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From heroine, cocaine, crack now to OTC herbal drugs in hour communities.
BEMA International
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Friday, July 10, 2026
Introduction: OTC Herbs and remedies misuse. Are our children accessing near schools. July 2026
Increase in Poison Center Reports Linked to Kratom-Containing Kava
Products — National Poison Data System, United States, 2000–2025
Weekly / April 2, 2026 / 75(12);157–163
Eleanor Blair Towers, PhD1,2,*; Ivy L. Williams1,*; Christopher P. Holstege, MD1; Rita Farah, PhD1 (View author affiliations)
View suggested citationSummary
What is already known about this topic?
Kava, a plant native to the Pacific Islands, is traditionally consumed in religious and cultural ceremonies. In the United States, it is sold as unregulated concentrated extracts and ready-to-drink beverages and commonly marketed as a healthy alternative to alcohol. Reports of liver toxicity and co-use with kratom, a psychoactive plant with opioid-like properties, have raised safety concerns.
What is added by this report?
Analysis of 2000–2025 National Poison Data System exposure data identified a resurgence of kava-related exposure reports since 2011, with recent exposures primarily involving men aged ≥20 years. Rates of serious medical outcomes have approximately doubled, coinciding with rising co-use of kava with kratom.
What are the implications for public health practice?
Enhanced surveillance, increased clinical awareness, and targeted education might help reduce risks from kava and its emerging co-use with kratom, particularly among U.S. men.
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Abstract
Kava (Piper methysticum), a central nervous system depressant
derived from a plant in the pepper family native to the Pacific Islands,
is traditionally consumed in religious, cultural, political, and social
ceremonies. In the United States, kava emerged in the late 1990s and
has experienced renewed growth and product diversification since the
2010s, with increasing availability of concentrated extracts and
ready-to-drink beverages. These commercial products are commonly
marketed as healthy alternatives to alcohol, sold near college campuses,
and increasingly being combined with kratom, a psychoactive botanical
with opioid-like effects, raising safety concerns. Data on kava-related
use during January 2000–December 2025 that resulted in a report to the
National Poison Data System (i.e., kava exposure report) were analyzed
to assess trends by users’ demographic characteristics, exposure type,
and outcomes. Kava-related exposure reports declined sharply after a
2002 Food and Drug Administration advisory on kava-associated severe
liver injury but have risen steadily since 2011, reaching 203 reported
exposures in 2025. Reports primarily involved adults aged ≥20 years, but
demographic characteristics have changed over time. During 2000–2001,
reports primarily involved females and included more children aged ≤12
years, whereas exposure reports since 2013 have predominantly involved
men; reports involving children have been rare. Since 2017, reports
involving combined use of kava and kratom have increased, reaching 30%
(61) of all kava reports in 2025. These increases have coincided with
higher rates of serious reported clinical outcomes in recent years (32%
in 2025 compared with 12% in 2000). These data indicate a resurgence of
overall kava exposure reports to poison centers, as well as an increase
in kratom-related kava reports, which has coincided with higher rates of
serious clinical outcomes. The findings in this report suggest the need
for enhanced surveillance for, clinical awareness of, and public
education regarding commercial products containing kava.
Introduction
Kava (Piper methysticum) is a psychoactive plant native to the Pacific Islands, where its root traditionally has been prepared as a water-based beverage consumed in cultural and social settings, with relatively low reported health risk (1). Since the 1990s, commercial kava products have become increasingly available in the United States, including concentrated extracts, capsules, and recreational beverages sold through retail outlets and dedicated kava bars, which are often promoted as alcohol-free social venues (2,3). These commercial products are unregulated and differ substantially from traditional aqueous preparations in terms of plant material, extraction methods, and alkaloid concentration (1,4,5). For example, kavalactones, the primary active constituents of kava that exert sedative and anxiolytic effects, can be present in commercial products at 2–10 times the concentrations present in traditional preparations (1). In addition, although some clinical trials support short-term anxiolytic efficacy of traditional preparations, commercial products are often consumed without medical oversight and have been associated with gastrointestinal and neurologic adverse effects, hepatotoxicity, and drug interactions via cytochrome P450 inhibition and additive central nervous system depressant effects (1,4,6).
In 2002, after reports of acute liver failure and liver transplantation temporally associated with kava use, the Food and Drug Administration (FDA) warned that kava-containing dietary supplements might be associated with severe liver injury (4). In 2020, FDA further concluded that indiscriminate kava use is not safe for use as a recreational or relaxation beverage for human consumption (5). Despite these cautions, the commercial kava market has continued to expand and diversify, including the emergence of combination products including kava and kratom, a psychoactive plant with opioid-like effects (7). The growing availability of commercial kava products with limited available safety data underscores the need to characterize national patterns of kava use reported to U.S. poison centers to identify groups at high risk for serious clinical outcomes and guide public health practice. This report analyzes characteristics of kava-related exposures, defined as actual or suspected substance ingestion, as reported to the National Poison Data System (NPDS), for exposures during January 2000–December 2025, stratified by age, sex, and outcome.
Methods
Data Source and Study Design
NPDS is the national database that aggregates deidentified exposure data from all 53 U.S. poison centers. Each exposure is defined as a reported actual or suspected substance ingestion for which a poison center was consulted, regardless of toxicity or clinical manifestation. Data are submitted in near real-time after consultative services are provided to members of the general public and health care providers.
For this retrospective review, NPDS was queried for all human exposures to kava during January 1, 2000–December 31, 2025. Each exposure could involve kava alone (single-substance exposure) or in combination with other substances (multiple-substance exposure). Patient demographic data (age and sex), exposure characteristics (substances and reason for use), level of care received, clinical effect, and medical outcome were included in the analysis. The analysis was conducted on deidentified and publicly available data, and the University of Virginia Institutional Review Board determined that the research did not require human subjects review.
Analysis
Data were descriptively analyzed. Numbers and percentages of all kava exposure reports were calculated to assess temporal trends, and kava exposure reports were stratified by sex, age, clinical effects, medical outcome, level of care received, and reported co-used substances. Age was categorized into four groups: 0–12, 13–19, 20–39, and ≥40 years. Medical outcomes were classified as serious or nonserious.† Level of care was categorized as hospitalized (critical care, noncritical care, or psychiatric unit admission) or not hospitalized (treated and released, refused referral, lost to follow-up, or managed outside a health care facility). Rates for kava exposure reports were calculated per 100,000 drug exposures.
Results
Number and Rates of Exposures
During the entire study period (2000–2025), a total of 3,101 kava-related exposures were reported. Before the 2002 FDA advisory, 298 and 331 annual case exposures were reported during 2000 and 2001, respectively, corresponding to approximately 34 kava-related exposure reports per 100,000 drug exposure reports (Figure 1). Coinciding with the advisory, annual exposure reports began to decline, reaching a low of 42 in 2010 (87% decrease during 2001–2010), before beginning to rise in 2011, increasing 383% by 2025 (from 57 to 203). Exposure report rates in 2010 declined to three per 100,000 drug exposure reports, but began to rise in 2011, increasing 220%, from five to 16 per 100,000 drug exposure reports in 2025.
Demographic Characteristics of Persons with Kava Exposures
In 2000–2001, females accounted for the majority of exposure reports (56%–57%), and a substantial proportion (25%–27%) involved children aged ≤12 years (Figure 1). During 2002–2025, the percentages of all exposures involving females and children aged ≤12 years declined, reaching 40% and 7%, respectively, in 2025. During both periods (2000–2001 and 2002–2025), adults aged ≥20 years accounted for the largest percentage of exposure reports (annual average = 66%; range = 41%–81%).
Outcomes
Across the analytic period (2000–2025), an average of 20% of exposed persons were hospitalized each year (range = 14%–30%), with no apparent temporal trends (Figure 2). In contrast, the percentage of exposures associated with serious medical outcomes increased from 12% in 2000 to a high of 39% in 2024. Eight deaths were reported during the analytic period, including one each in 2000, 2001, 2005, 2017, 2023, and 2024, and two in 2021 (fatality rate = 0.25%).
Substance Co-Exposure
During 2000–2025, a total of 1,347 (43%) kava-related exposure reports involved multiple substances. The most common co-involved substances were ethanol (annual average = 7%; range = 3%–13%) and benzodiazepines (annual average = 5%; range = 2%–14%) (Figure 3). However, in 2017, kratom emerged as a common co-exposure and, by 2019, kratom surpassed ethanol and benzodiazepines in multiple-substance kava-related exposures. This coincided with increasing availability of products containing kava and kratom (Supplementary Figure 1). In 2025, co-use of ethanol or benzodiazepines accounted for 3% of multiple-substance exposures, and kratom accounted for 30%.
Reported Clinical Effects
The most common clinical effects among single-substance exposures (1,754) were gastrointestinal (vomiting and nausea), neurologic (drowsiness or lethargy, dizziness or lethargy, and agitation), and cardiovascular (tachycardia) signs and symptoms (Supplementary Figure 2). Multiple-substance exposures involving only kava and kratom (128) had similar symptomatology; however, neurologic effects included seizures and tremor, and cardiovascular effects included hypertension. Liver injury was less common for both exposure types. Moderate elevations in aspartate transaminase or alanine transaminase (>100 to ≤1,000 IU/L) were reported in 29 of 1,754 (1.7%) single-substance exposures and eight of 128 (6.3%) multiple-substance exposures involving kava and kratom.
Discussion
Poison center surveillance functions as a national early warning system for emerging substance-related harm. After a sharp decline in kava-related exposures reported to NPDS after the 2002 FDA advisory on kava-associated liver injury (4), reported exposures have increased substantially since 2011. This increase parallels the expanded availability of commercial kava products in the United States (2,7), despite the FDA conclusion that these recreational or relaxation beverages are not safe for human consumption (5). Recent exposures have predominantly involved men aged ≥20 years and have been characterized by higher rates of serious medical outcomes, associated with increasing reports of co-use with kratom.
The resurgence of kava-related exposures reported to poison centers also coincides with the expansion of the nonalcoholic beverage market, as consumers increasingly seek alternatives to alcohol (8). These products are frequently sold online and in vape shops near college campuses (9), mirroring demographic patterns observed in exposure data, and are commonly marketed as a way to feel social without alcohol or a hangover. NPDS data findings are consistent with FDA reports indicating that kava ingestion can cause substantial gastrointestinal and neurologic effects, particularly when used in nontraditional preparations that contain higher doses or are combined with other substances such as kratom (4,5). In contrast to some countries where kava products are subject to regulatory dose limits (e.g., a maximum daily intake of 250 mg kavalactones from water-based extracts and 125 mg limit per individual tablet or capsule), kava and kava-kratom combination products sold in the United States are unregulated and advertised to contain >250 mg kavalactones per serving (30 ml), often with multiple servings per container (5). Actual kavalactone content might be even higher, because these products are not subject to standardized manufacturing or content verification as is alcohol. Furthermore, hepatotoxicity and other adverse effects have been linked to the chronic consumption of high-potency commercial products (4,5). In this analysis, transaminase elevations were reported in a small proportion of cases; however, no cases of acute liver failure were identified. These findings are consistent with rare reports of idiosyncratic hepatotoxicity associated with kava use. Continued promotion of these products without adequate verification of product content, consumer education regarding potential adverse health effects, and clinical awareness of evolving exposure patterns represents an ongoing public health concern.
Limitations
The findings in this report are subject to at least four limitations. First, NPDS is subject to reporting bias, with the accuracy of data being subject to correct input and coding of medical outcomes and the highest level of care received. Second, because reporting to poison centers is voluntary, NPDS likely does not include all kava-related exposures, particularly those that are mild or self-managed. Third, poison centers upload deidentified data to NPDS; therefore, it is not possible to distinguish between first-time and repeat exposure reports. Finally, NPDS generic codes do not permit distinction among product types. Therefore, it was not possible to capture information on product type, including preparation method or dose, limiting conclusions about formulation- and dose-specific risk.
Implications for Public Health Practice
The reemergence of kava-related exposures with clinical effects reported to poison centers in the United States, coinciding with increased availability of commercial products with high kavalactone content and co-use with kratom, represents a public health concern. Continued surveillance and increased clinical awareness could improve recognition, reporting, and characterization of high-risk product formulations and use patterns. Targeted public health education might help inform consumers that commercially available kava products are not regulated and are not recognized as safe for use as recreational beverages by FDA, and that the formulations commonly sold in the United States have been associated with adverse health effects, especially when used in large quantities. These efforts are particularly important for young
Corresponding author: Christopher P. Holstege, ch2xf@uvahealth.org.
Thursday, July 9, 2026
Part 2: Awareness: DANGER..... OTC Drugs that Children may be ingesting from 7-11's, Convenience Stores, and Service Stations. July 9, 2026
Mental or Physical health crisis.
Be aware. Even the energy shots, and many of the ‘POWER’ drinks may be detrimental to your overall health and well-being.
Many MIMIC POWERFUL ADDICTIVE OPIOIDS.
READ THE LABELS
Eat well, stay healthy for you and your loved ones.
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https://share.google/aimode/sIs1rJvge4BxH9pLL The U.S. Drug Enforcement Administration (DEA) has filed intent to temporarily place highly concentrated, synthetic kratom compounds into Schedule I of the Controlled Substances Act (CSA), effectively banning them nationwide. On July 1, 2026, the DEA filed two Notices of Intent targeting the specific potent compound 7-hydroxymitragynine (7-OH) and related synthetic chemicals. The emergency ban is scheduled to take effect as early as August 5, 2026, and will remain in place for at least two years. What is Being Banned The DEA's reclassification specifically targets highly concentrated and fully synthetic alterations of the kratom plant, which public health officials warn mimic powerful, addictive opioids. The emergency scheduling applies to:
These compounds are commonly manufactured into concentrated
often sold at gas stations and smoke shops under the guise of "kratom extracts". What is Excluded
Key Timeline and Legal Impacts
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Friday, July 3, 2026
Thursday, July 2, 2026
Community Imperative: GCHIC Data Center 101 videos and Underground Data Center possibilities. June 2026
One
Community Perspective. Information and awareness.
Greater
Capitol Heights Improvement Corporation (GCHIC) Four episodes Data Center 101 at gchic.org/data-centers
DATA CENTER 101
Underground Data Center. (NOTE: NOT an endorsement by BEMA Int)
 Statement on Underground Data Centers Thank you to the residents who have raised questions about the possibility of underground data centers in Prince George’s County. While I appreciate the creativity behind exploring alternatives to above‑ground facilities, my position remains firm: I do not support the development of hyperscale data centers in Prince George’s County — whether above ground or underground. Our communities already shoulder significant environmental, health, and infrastructure burdens. Underground data centers do not eliminate these impacts; they simply relocate them. In many cases, they introduce new risks. Economic Concerns
Environmental & Infrastructure Impacts
Safety Risks
Community Voice Matters Reduced public opposition should never be a justification for siting major industrial facilities. Community voice is not an obstacle — it is a requirement. Land‑use decisions must prioritize the health, safety, and long‑term wellbeing of residents. My Commitment If……………………………safeguarding our environment, and ensuring that economic development aligns with community needs — not the demands of energy‑intensive industries. Sincerely, Eleanor Washington |
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